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Further, qPCR analysis revealed significantly upregulated expression of detoxifying enzymes such as cytochrome P450, glutathione S-transferase and carboxylesterase-related genes in viruliferous insects compared to non-viruliferous insects

However, contrary to this opinion, we believe that in the specific case of COVID-19 it is of paramount importance taking due account of the fact that PAC and its metabolites decrease GSH levels, also when given at relatively low doses in healthy volunteers (Nuttall et al., 2003

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