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Much of it is indirect, preclinical, observational, or focused on biomarkers rather than clinically meaningful outcomes [8][1012][1415]
These include superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and heme oxygenase-1 (HO-1), among others
The oral semaglutide solution involved co-formulating the peptide with SNAC (sodium N-[8-(2-hydroxybenzoyl)aminocaprylate), an absorption enhancer that protects semaglutide from enzymatic breakdown in the stomach and facilitates transcellular absorption through the stomach wall
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