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The SUSTAIN 5 trial [170] (ClinicalTrials.gov identifier: NCT02305381) was a 30-week, double-blind, placebo-controlled trial of once-weekly subcutaneous semaglutide 0.5 mg or semaglutide 1.0 mg versus placebo in patients with type 2 diabetes
This imbalance is hypothesized to contribute to dysfunctions in the reward system, potentially manifesting as anhedonia and other depressive symptoms 45 , a clinical observation that aligns with the psychiatric side effects noted in GLP-1 RAs therapy
Cagrilintide is used to investigate receptor signaling and metabolic pathways in controlled laboratory settings
PLoS ONE 9 , e104771 (2014)
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