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Therefore, this review aims to synthesize the evidence on the mechanistic expansion of GLP-1RAs from metabolic regulators to systemic modulators of inflammation, autophagy, and organ protection, and explores their therapeutic repurposing across diseases
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In peptide research studies, Semaglutide is frequently examined for its interactions with GLP-1 receptor pathways, making it a compound of interest in laboratory research focused on metabolic regulation, endocrine signaling, and cellular response mechanisms
16 Nonetheless, other GLP-1 RAs such as albiglutide has also shown reductions on MACE risk up to 22% as demonstrated by the HARMONY trial
