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An animal study revealed that when DSIP was directly injected into the bulbo-mesencephalo-thalamic recruitment system, it induced slow-wave sleep and Naloxone-reversed sleep spindle activity

Zhou J, Zhang L, Peng J, Zhang X, Zhang F, Wu Y, et al

The LR3 extension does not make it "safer" -- it makes it longer-acting and less regulated by binding proteins, which from a risk standpoint means sustained free IGF-1R activation without the IGFBP buffering system that modulates native IGF-1 activity in healthy physiology

I've been using this now for over a year and notice a real difference in my energy and my B12 levels are up in my tests

Michaowicz J, Wuka A, Cyrkler M, Maczak A, Siciska P, Mokra K