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GLP-1, binds to GLP-1R mostly in an -helix conformation with a large surface of contact with both the extra-cellular domain and the seven transmembrane domain 27,30
When stress is chronic, this can lead to significant issues with digestive and hormonal function
These findings help refine experimental designs focused on integrated incretinglucagon signaling and metabolic efficiency
There is evidence underpinning adjunctive GLP-1 therapy post-bariatric surgery [20]
Much of that wont be known for another 1015 years
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