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GIP appears to have a bifunctional stabiliser effect on glucose levels: under hyperglycaemic conditions, it potentiates insulin release whilst not affecting glucagon release, whereas under hypoglycaemic conditions, it increases glucagon release and does not affect insulin secretion [47]
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95% confidence interval [CI] 0.720.78)
In terms of the anorectic pathways in the brain, the anorectic effects of MC4R agonism are mediated by downstream responses of POMC/CART neurons [26, 27]
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