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In a phase 1b placebo-controlled, randomized clinical trial, participants with overweight or obesity received OW SC cagrilintide at various doses or placebo, in conjunction with semaglutide 2.4 mg over 20 weeks [123]
This produces tolerance subjects require progressively higher doses to maintain pigmentation, which increases off-target side effect risk
This guarantees safety and effectiveness
PMID: 14988435 Shuster S, Black MM, McVitie E
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