Conclusion In this large real-world study emulating a target trial, initiation of GLP-1 RA therapy among patients with T2DM was associated with a modestly higher incidence of psoriasis and lower incidences of pemphigus and bullous pemphigoid compared with DPP-4i therapy, while no increased risk was observed for most other autoimmune or inflammatory skin diseases
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Endocrinology 1978;103:6105.ArticlePubMed 24
Most providers recommend overlapping the transition rather than switching abruptly
Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, Biswal S (2009) Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice