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Genetic predisposition does not predict exact medication response but may support a more informed treatment conversation
Aardvark Therapeutics Sector: Oral gut-restricted bitter taste receptor agonists for hunger suppression HQ: San Diego, CA Year Founded: 2017 Origin Story: Aardvark Therapeutics was founded around a mechanistically distinct hypothesis: rather than suppressing appetite like GLP-1 drugs, the companys lead compound activates bitter taste receptors (TAS2Rs) confined to the gastrointestinal tract to trigger local release of satiety hormones, targeting hunger itself without systemic drug exposure
It proceeds via sequential steps: phagophore formation, autophagosome maturation, lysosomal fusion, and cargo degradation in autolysosomes
This is capitalism at its best, said Ball, who studies the FDA and regulated drugs
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