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Summarizing past and present hypotheses, decreased electron flow through CIII may be the result of 1) a direct effect of NO (original hypothesis), 2) an indirect effect of the mechanism responsible for NO production (S-nitrosoglutathione/dithiothreitol system), 3) increased formation of peroxynitrite from NO and superoxide, or 4) an effect of NO on the electron transport carrier ubiquinol-10 (Poderoso et al., 2019)

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11 Conversely, other researchers have used the AOM model and observed no changes in immunoblot tight junction protein expression

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