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A 2023 study of 156 men with low testosterone found that those adding MK-677 to their testosterone protocol gained 23% more lean muscle mass over 16 weeks compared to testosterone alone

Values represent plasma insulin levels induced by glucose given orally (50 g/400 mL) (red circles) or an equivalent amount (isoglycemic) given intravenously (IV) (black circles)

Discussion Diabetes and obesity have become main global threats to health in recent decades

Clinical trials have shown clinically meaningful reductions in HbA1c levels across various dose groups, with some participants achieving reductions of up to 2.2%