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Clarification, April 1, 4:15 pm ET: A previous version of this post referred to the semaglutide revolution. The story has been updated to clarify that not all the medications for weight loss discussed are semaglutides.

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However, no direct head-to-head comparisons have been conducted, and the 48-week timeframe in the retatrutide trial is shorter than the 6872 week endpoints used in the semaglutide and tirzepatide phase 3 trials, making direct numerical comparison imprecise

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