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Indeed, a recent meta-analysis reported that, while proportional to initial loss and varying by type of AOM, weight regain can range from 2.2 kg to 9.7 kg [101]
Phase 2 clinical trials observed mean body weight reductions of up to 24% over 48 weeks significantly outperforming semaglutide and tirzepatide in head-to-head comparisons
During that extended transit time, the colon extracts water relentlessly, leaving behind hard, dry, pellet-like stool that resists passage
It is briefly mentioned in the Drug Interactions section to say the drug delays gastric emptying, and may impact absorption of concomitantly administered oral medications. It is also briefly mentioned in the Pharmacodynamics section, which describes how the drug works
For patients starting tirzepatide, this delayed peak means that full therapeutic benefit may not be apparent in the first one to two weeks
