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The American Diabetes Association (ADA) guidelines recognize GLP-1 receptor agonists as preferred agents for patients with type 2 diabetes who require additional glucose-lowering therapy beyond metformin, particularly those with established cardiovascular disease or chronic kidney disease, with preference given to agents with proven cardiovascular benefit
When taken as a supplement, GLP-1 can optimize digestion through various mechanisms
A 2025 case series found that those with genetic predispositions, for example, cystic fibrosis or hemochromatosis, may be more susceptible
It is still in the Canadian CSP register, scheduled to take effect in March 2026 and last until March 2028
Among them, the allele frequency of Q141K , V12M , and Q126X is 31.9, 19.2, and 2.8% (Matsuo et al., 2009)
