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The shRNA constructs against NRF2 were designed targeting guggcugcucagaauugcaga (sh NRF2 -1), guaagaagccagauguuaaga (sh NRF2 -2), and gcuccuacugugaugugaaau (sh NRF2 -3) (#230086 and 230087, Addgene)
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Ganju and colleagues concluded, These results provide the first large-scale evidence supporting GLP-1RAs as a safe and potentially beneficial adjunct in Crohns disease management. They went on to note that prospective studies and guideline development are urgently needed to define their role in integrated IBD and metabolic care.
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