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Liu J, Yao S, Wang M, et al
in total, 9 genera (including the unclassified group) and 38 metabolites met these criteria (metabolites published in Sampson et al., 2021 13 )
NNMT sits on the same one-carbon metabolism that governs SAM, homocysteine and DNA methylation, and the long-term consequences of suppressing it are unstudied
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This approach mirrors how anti-obesity medications are used in clinical practice, where long-term maintenance therapy prevents weight regain
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