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Glucagon-like peptide 1 agonists Research has shown that GLP-1 agonist therapy is effective in managing obesity, satiety issues, and elevated blood glucose levels in patients with PWS [8,5053]
In fact, a double-masked, placebo-controlled study found that Byetta (exenatide, AstraZeneca), a GLP-1 receptor agonist for diabetes, lowered intracranial pressure (ICP) by 5.7 cm H 2 O within 2.5 hours in women with active IIH ( P = .048), a benefit that was sustained across 12 weeks
It upregulates peroxisome proliferator-activated receptor gamma coactivator 1 alpha, the master regulator of mitochondrial biogenesis, which in turn stimulates mitochondrial proliferation [138]
That does not prove those routes cannot work