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Some studies suggest that semaglutide could improve insulin sensitivity

It is also used to reduce the chance of major heart-related events, such as heart attacks and strokes in overweight or obese individuals with existing cardiovascular disease

Instead, Zepbound, the FDA-approved version of tirzepatide for weight management, may be considered for those seeking that benefit

The weight loss mechanism differs as well: GLP-1 agonists work through delayed gastric emptying and central appetite suppression, while berberine's weight effects, when present, likely relate to improved insulin sensitivity and metabolic efficiency

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