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A clinical study shows that semaglutide increased gastric content retention by approximately 3.5% at 1 hour, 25.5% at 2 hours, 38% at 3 hours, and 30% at 4 hours compared to 0% retention with the placebo
[54] in women with PCOS, BMI 25 kg/m 2 and/or insulin resistance, treatment with liraglutide 1.8 mg/day for 26 weeks, along with a higher weight loss, induced significant reductions in fasting plasma glucose, HbA1c, and plasma glucose AUC, whereas Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), Matsuda index and insulin AUC remained unchanged
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