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These findings suggest that endothelial IGF- 1R signaling is essential for regulating skeletal muscle perfusion, and its loss results in diminished vasodilatory capacity, potentially contributing to reduced exercise performance and muscle endurance
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Modulation of its activity slows gastric motility, leading to prolonged food transit and reduced hunger
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Currently, it is generally accepted that the main functions of GLP-1 mediated by GLP-1R modulation include regulation of nutrition, weight, glucose and lipid metabolism, cardiovascular functions, cognitive functions, as well as stress and emotional reactions
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