In addition to impacting the speed of absorption of oral supplements, the digestive process also affects the extent of absorption, with 40%-50% of low-dose B12 vitamins being absorbable
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However, when both polymorphisms were considered simultaneously, carriers of the combined MTR 2756AA/ MTRR 66GG genotype showed increased serum folate levels, while carriers of the MTR 2756GG/ MTRR 66AA genotype had both reduced folate and hcy levels (Copped et al., 2014)
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