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12 Earlier data from the STEP 1 trial extension showed people regained roughly two-thirds of the weight they had lost within 12 months
2 Identification of the other hormone, GLP-1, was a more complex task because of the difficulty of differentiating it immunologically from other bioactive products and inactive degradation fragments of its precursor, proglucagon
Tirzepatide has shown similar results: in a phase 2 trial, up to 73.3% of participants at the highest dose achieved MASH resolution without worsening fibrosis at 52 weeks, compared to 13.2% on placebo
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For others, the same medications appear to dampen desire through neurochemical mechanisms that are only beginning to be understood
