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354 These aggregates not only evade degradation but also obstruct the processing of other UPS substrates

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Furthermore, recent CRISPRCas9 knockout screening led to the identification of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1), which is as an important contributor to the defense system against ferroptosis (Fig

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Furthermore, SGLT2 inhibitors may attenuate sympathetic nervous system hyperactivity, a common feature in people with type 2 diabetes mellitus and CKD, potentially through decreasing oxidative stress and inflammation [31,32]