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The hormonal binding at the extracellular domain is communicated to the intracellular receptor side, leading to G protein engagement and activation (45)
Additionally, the longitudinal analysis approach may have been subject to potential loss to follow-up and limitations in representativeness
This could happen if the treatment and control groups are not comparable- for example if doctors prescribed GLP-1s vs another diabetes medication for systematic reasons such as the health profile of the patient
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Wechsler IS
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