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Ethics, reproducibility and methodological pitfalls Frequent pitfalls in cognitive peptide research No vehicle control in some old Russian studies: mandatory in any modern publication Non-randomisation : assigning animals to groups by order of arrival introduces systematic bias (weight, oestral cycle, cage stress) Non-blinded experimenter : behavioural tests are highly sensitive to expectations
The peptide works by supporting natural sleep processes rather than forcing sedation, which is why it doesn't cause the dependency or withdrawal issues seen with pharmaceutical sleep aids
Biochemical and biophysical research communications, 2025, 742: Article 151060
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