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Common Menstrual Changes While Taking GLP-1 Medications Patients on semaglutide report several patterns: delayed or skipped periods (amenorrhea), lighter bleeding, shorter cycles, or longer cycles

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In the key Phase 3 ATTAIN-1 trial published in the New England Journal of Medicine in 2025, once-daily orforglipron 36 mg produced mean body weight reductions of 11.2% at 72 weeks in adults with obesity, with nearly 55% of participants achieving at least 10% weight loss and 36% achieving 15% or more