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Inflammatory bowel disease Under inflammatory conditions such as IBD, microbiome-derived butyrate and propionate act as bacterially derived danger signals that, in the presence of TLR activation, promote NLRP3 inflammasome activation and IL-1 release through HDAC inhibition, which prevents transcription of FLICE-like inhibitory protein (cFLIP) and IL-10 while enabling caspase-8-dependent inflammasome activation [299]

Int J Parasitol Drugs Drug Resist 17:128138

Antagonist at adenosine receptor subtype A1

Results Patient characteristics Thirty seven patients completed baseline scanning