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J Immunol 185(6):31903198 Liu Y et al (2018) Tumor-repopulating cells induce PD-1 expression in CD8(+) T cells by transferring kynurenine and AhR activation
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That improves pain, but does not by itself prove a direct GLP-1 tissue effect
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Cases were generally mild to moderate, most resolved while treatment continued, and most participants stayed on the drug but it is a real, dose-related effect and its mechanism is not yet fully explained
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