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A: Tirzepatide showed average weight loss of up to 22.5% of body weight in the SURMOUNT-1 trial
Completely metabolized by liver enzymes Bioavailability 27%-47% Protein binding: 97% Excreted in urine (50%), feces (30%) (metabolites) Half-life 8-12 hr
The neurobiology of GLP-1 signaling, hormonal regulation of reward, and dopamine modulation had yet to emerge
Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF- and IL-6
of quadruplicate measurements
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