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Total carnitine abundance was significantly affected by KG (Extended Data Fig

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no amino-acid sequence Reference salt: Iodide salt CAS for iodide salt: 42464-96-0 PubChem CID for iodide record: 66522933 PubChem CID for cation: 950107 Iodide-salt formula: C10H11IN2 Iodide-salt molecular weight: 286.11 g/mol Cation formula: C10H11N2+ Cation molecular weight: 159.21 g/mol Primary research target: Nicotinamide N-methyltransferase (NNMT) Reference potency: approximately 1.2 M IC50 under a specified in-vitro assay Purity specification: 99% by HPLC, subject to lot-specific report Identity specification: Mass-spectrometry confirmation, subject to lot-specific report Product format: Lyophilized or dried research powder as stated on the lot label Release: QC-released under SaiyanMed specifications General sealed storage: 20C, protected from light and moisture Expiration: Use the date and stability statement on the lot-specific label or COA Salt Form & Molecular-Weight Basis Name Formula Molecular weight Identifier Use in calculations Do not mix salt mass and cation-equivalent mass A vial labeled by iodide-salt mass is not numerically equivalent to the same mass of free cation

After this acclimation period, mice from different groups were administered once daily with vehicle or equivalent doses (10 nmol/kg) of GLP1/E, GLP1/GIP, or GLP1/GIP/Glucagon for 3 consecutive days