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Blocking NNMT raises intracellular NAD+ and SAM pools, theorized to drive lipolysis and improve insulin sensitivity in adipose tissue
The standard titration schedule starts at 2.5 mg per week for 4 weeks, then increases to 5 mg per week for another 4 weeks, with subsequent increases of 2.5 mg every 4 weeks up to a maximum of 15 mg per week (Mounjaro prescribing information, Eli Lilly)
Long-term weight loss maintenance data beyond 68 weeks for Retatrutide are still limited
Inject at least 2 inches away from the navel
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