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Mutations in both GLP1R and GIPR, a gene related to insulin secretion and energy production, were associated with nausea and vomiting

Essentially, glucagon-like peptide-1 (GLP-1) receptor agonists (RA) and glucose-dependent insulinotropic polypeptide (GLP-1/GIP) dual RA target the fundamental pathophysiology that underpins both T2D and obesity

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