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Bugger H, Abel ED
40,105 However, given that IGF-1R and insulin receptor have decreased affinity for each others main ligand in comparison to their main ligand, it is likely that insulin and IGF-1 cannot stimulate the anabolic effects of each others receptor activation to the same degree as the main ligands for insulin receptor and IGF-1R at physiological concentrations
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Most people start on a low dose to minimize side effects and gradually increase over time
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