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In vitro studies have found that inhibiting the transcriptional activity of Nrf2 can reduce the synthesis of glutathione, thereby causing the apoptosis of IDH1 mutant cancer cells

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Neuroscience 158:514523 Calabrese V, Giuffrida Stella AM, Calvani M, Butterfield DA (2006) Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes