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This conformational change in the LBD has also been seen in other nuclear receptors, such as the retinoic acid receptor (RAR) bound to all-trans retinoic acid (PDB: 2LBD) 74 , thyroid hormone receptor (TR) bound to 3,5,3-triiodothyronine (PDB: 3GWS) 75,76 and peroxisome proliferator-activated receptor- (PPAR) bound to the agonist ligand GW409544 (PDB: 1K7L) 77