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Clinical data from the STEP trials, which enrolled over 4,500 participants, demonstrated that patients who followed standard titration achieved higher cumulative weight loss and continued treatment longer than those reporting accelerated schedules
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To evaluate the efficacy of melatonin across these age groups, cumulus cells were isolated from patients and subjected to gene expression analysis for cuproptosis-related genes (ATP7B, SLC31A1, FDX1, DLD, DLAT) and ferroptosis-related genes (TFRC, GPX4, NCOA4, SLC3A2, SLC7A11)
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