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A combined topical + oral study showed better effect than monotherapy
However, tirzepatide injections show weight loss in clinical trials
The SHAPE study, analyzing real-world prescribing data, found: At 3 months: tirzepatide users lost 5.9% of body weight versus 3.6% for semaglutide At 6 months: 10.1% versus 5.8% At 12 months: 15.3% versus 8.3% These are averages from actual patients, not trial participants
Maintaining balanced nutrition is key, even while reducing portion sizes
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