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This observation may explain why semaglutide and other GLP-1 RAs ranked among the lowest-impact DM2 DMTs in our model compared to drugs such as metformin, which engage a broader range of metabolic and neuroprotective pathways (e.g., AMPK, insulin, and adipocytokine signaling)
Variables significant in the univariate analysis were then included in the multivariate model to assess their independent impact on survival after adjusting for other covariates
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Lifestyle, diet, and environmental factors compound these immunemetabolic interactions
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