"Micronutrient Supplementation Increases CD4 Count in HIV-Infected Individuals on Highly Active Antiretroviral Therapy: A Prospective, Double-Blinded, Placebo-Controlled Trial." J Acquir Immune Defic Syndr 42.5 (2006): 523-8
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A deficit in NAAG levels would therefore (1) increase the activity of NMDA receptors, leading to over-activation of GABAergic interneurons and consequently disinhibit pyramidal neurons, (2) and reduce the agonist action on mGluR3 receptors located pre-synaptically in glutamatergic neurons, thus removing the negative feedback
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