DSIP should therefore not be regarded as a reliable sleep aid, but as a research molecule whose neuroendocrine effects continue to be investigated
Human evidence - Phase 3 TRANSCEND-T2D-1 (Eli Lilly, March 19, 2026) 537 adults with type 2 diabetes, randomized 1:1:1:1 to retatrutide 4, 9, or 12 mg or placebo
Then, they get it once a week for a month
Across six randomized, double-blind, placebo-controlled trials, AOD-9604 showed no effect on serum IGF-1, no impairment of glucose tolerance, and no insulin resistance all common problems with full GH therapy (Stier et al., 2013)
Possible Mechanisms Tirzepatides influence on heart rate may be linked to its action on GLP-1 receptors, which are present in the heart and blood vessels