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4-Phosphopantetheine is then converted to coenzyme A via the action of the bifunctional enzyme, coenzyme A synthase encoded by the COASY gene

Nutrient Deficiencies Your body needs specific nutrients to metabolize histamine: Vitamin C acts as a natural antihistamine and supports DAO function Vitamin B6 is required for DAO synthesis and histamine breakdown Magnesium stabilizes mast cells and reduces degranulation Zinc modulates immune function and mast cell activity Ironically, copper deficiency can worsen mast cell reactions, even when injecting the copper peptide GHK-Cu

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Yin, N., Harris, P