flow trial semaglutide kidney outcomes hazard ratio 0.76 significant 24% reduction in disease progression and death related to kidney and cardiovascular causes in those treated with compared to a placebo Media Centre | EASD

Several practical factors may explain fatigue during GLP-1 therapy: Reduced food intake due to appetite suppression can lead to lower energy consumption Gastrointestinal side effects like nausea can be physically draining Adaptation to metabolic changes as your body adjusts to the medication For people with diabetes who take insulin or sulfonylureas (like gliclazide) alongside GLP-1 medications, low blood glucose (hypoglycaemia) may cause fatigue

Still, if that's what you're getting, then I would suspect that as potentially the problem

Plain water is not enough: you need electrolytes

Presented for research literature review only Cohen BE et al

Endocrinology 18 DrakeN