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The chondrocytes used in this study were isolated from eight donors (15-, 70-, 73-years-old female, and 42-, 69- and 70-years-old male) without the sign of cartilage degradation
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In addition, the degradation of intracellular GPX4 through CMA pathways can lead to the accumulation of intracellular phospholipid peroxide and ferroptosis, and host cells usually use GPX4 for peroxide phospholipids reduction, thus protecting cells from death
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