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Moreover, a meta-analysis showed that the addition of STS seemed more effective in treating heart failure than Western medicine alone [153]
Gradual dose titration, as recommended in the prescribing information, helps minimise adverse effects regardless of administration time
This could be direct effects on the glycocalyx/endothelial function or potential anti-inflammatory effects. Heerspink noted most adults enrolled in the SURPASS trials had preserved kidney function, and additional studies enrolling adults with type 2 diabetes plus CKD with longer follow-up are needed
As an investigational compound, comprehensive safety data is incomplete
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