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health system an estimated $173 billion annually, with $1,800$3,000 in additional medical costs per adult each year
The pathogenesis of MTX-induced renal impairment is thought to be mediated by either MTX and its metabolites precipitating in the renal tubules or MTXs direct toxic impact on the renal tubules (Reference Widemann and Adamson6)
Urology Care Foundation
Vitiello PP, Cardone C, Martini G, Ciardiello D, Belli V, Matrone N, et al
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