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As described above, inhibition of IL-6 trans-signaling has been shown to mitigate inflammation responses (Risby-Jones et al., 2025), and targeting miRNAs has a potential to modulate glial cell functions (Hoye et al., 2018
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These hits were further refined through Lipinskis RO5, the BBB filter, the PAINS-Remover server, and a PDE10A pharmacophore model, yielding 647, 564, 537, and 4 hits, respectively
Each medication has its own therapeutic range
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