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However, it is important to note that: Clinical trials have limitations in detecting rare adverse events, particularly those that may take extended periods to develop Post-marketing surveillance continues to monitor for previously unidentified safety concerns Individual case reports may emerge, but these do not establish causation without rigorous epidemiological analysis Why the question arises : The association between Wegovy and diverticulitis may be questioned because: Gastrointestinal effects : Wegovy commonly causes GI side effects including nausea, constipation, and changes in bowel habits, which might theoretically affect colonic function
1995;9(Pt 5):637-638
Activation of the gut-brain-muscle axis occurs as GLP-1 signaling engages dual circuits linking vagal afferent inputs to hypothalamic pathways, coordinating neuroendocrine outputs such as insulin-like growth factor-1 (IGF-1) signaling and sympathetic nervous system (SNS) activity that help maintain muscle mass and strength during aging [158-160]
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As of May 19, 2026, the FDA had received 17,009 reports of side effects related to Wegovy, including 107 deaths
