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6,12 Conclusions Balanced meals that combine fiber, protein, and healthy fats can naturally increase GLP-1 activity, promoting satiety, maintaining optimal energy levels, and improving glucose control
PMID 10554220
The brain atrophy of GCLC-KO mice was also evidenced by MRI analyses (Fig
In vitro models show it enhances superoxide dismutase activity for antioxidant effects and stimulates metalloproteinases for matrix turnover
Using a model of streptozotocin diabetes in rats in vivo and HT-22 cells in vitro, it was shown that GLP-1RA liraglutide improves the cognitive abilities of rats with diabetes mellitus and can have a protective effect by reducing oxidative stress, suppressing the expression of -secretase (BACE1) and -secretase, as well as reducing the deposition of -amyloid by triggering signaling mechanisms associated with NF-kB and ERK1/2 [30]
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