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This combination works in an integrated manner to reduce appetite and increase satiety, improve glycaemic homeostasis, and promote greater energy expenditure/thermogenesis via activity at the glucagon receptor
It was envisaged that the afferents transmit to N -methyl-d-aspartate (NMDA) receptors in the nucleus of the solitary tract (NTS), with onward signalling to the efferent fibres of the hepatic vagal nerve, resulting in a reduction in hepatic glucose production
It crosses the blood-brain barrier and activates the hepatocyte growth factor (HGF) / c-Met receptor pathway, a signaling system that governs neuron survival, synaptic formation, and neural circuit repair
& Zorzano, A
Potential Research Applications: Lipid metabolism and fat mobilization studies Liver function and detoxification research Energy production and mitochondrial pathway exploration Metabolic health and nutrient utilization investigations For laboratory research only
